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NEWReticular's interpretability research accepted to ICLR 2025

Reliable AI Predictions to Accelerate Antibody Engineering

Reticular leverages advances in interpretable AI to reliably predict properties and engineer antibodies even with limited data

Antibody structure
Improved antibody structure
+16%
-19%
-23%
Improve affinity
Reduce aggregation
Reduce immunogenicity

Backed by the best

Plus angel investors from frontier AI labs and top biopharmas

Y Combinator
CRV
BoxGroup
SV Angel

See How It Works

Our platform makes it easy to optimize antibody sequences for multiple properties simultaneously

Reticular Antibody Optimization Suite

Upload Antibody Sequences

Start by uploading your antibody sequences or select from our example dataset

Antibody Sequences
Sequence ID
Sequence
Length
AB-001
EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVS...
118 aa
AB-002
DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYS...
112 aa
AB-003
QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLG...
124 aa

Our Platform Capabilities

Reticular's platform offers comprehensive tools for antibody engineering with interpretable AI

Data Import

Seamlessly import your lab data, regardless of format or volume

Liability Assessment

Our advanced ML algorithms rapidly identify sequence liabilities with high accuracy

Interpretable Models

Understand exactly why sequence issues exist and engineer solutions with transparent, steerable AI

Multi-Property Optimization

Simultaneously optimize multiple antibody properties, reducing time-to-market by 2-4 months

Properties We Optimize

Our platform can simultaneously optimize multiple antibody properties to meet your specific needs

Aggregation Hotspots

Identify and eliminate regions prone to aggregation

Affinity

Enhance binding strength to target antigens

Thermostability

Improve stability at various temperatures

Solvent Stability

Enhance stability in different buffer conditions

Specificity

Improve target selectivity and reduce off-target binding

Solubility

Optimize solubility for better formulation options

Expression

Improve expression levels in production systems

Humanization

Reduce immunogenicity while maintaining function

Why Trust Reticular

Our expertise is backed by scientific rigor and industry recognition

Born at MIT, Backed by the Best

Founded by MIT researchers and backed by Y Combinator and leading venture capital firms

Y
Combinator
CRV
MIT

Validated by Science

Our research has been published in top AI and biology conferences and journals

ICLR
NeurIPS
Nature

Trusted by Experts

Our platform is used by leading research labs and biotech companies

Top Universities
Biotech Startups
Research Labs

Your Data, Your Control

We prioritize the security and ownership of your data and intellectual property

Designed for Privacy

Only those you invite can access your data. Your data isn't used to train models for others.

Military-Grade Security

We utilize robust, military-grade encryption to ensure your data remains safe.

Full IP Ownership

You maintain complete ownership of your IP. Our pricing is simple—a clear annual fee, no royalties.

Join leading labs and researchers accelerating antibody discovery

Our platform helps you optimize antibody properties with unprecedented precision, even with limited data

Schedule a Demo

Limited early access spots available